Advanced oxidation protein products are antagonists of the HDL receptor SR-BI
نویسندگان
چکیده
Background Advanced oxidation protein products (AOPPs) are carried by oxidized plasma proteins, especially albumin, and are important risk factors for cardiovascular events in patients with renal disease. Renal patients have a high prevalence of coronary and carotid arteriopathy and face an excessive cardiovascular mortality. Therefore the role(s) of AOPPs in the development of cardiovascular disease might be of great importance.
منابع مشابه
Plasma-advanced oxidation protein products are potent high-density lipoprotein receptor antagonists in vivo.
Advanced oxidation protein products (AOPPs) are carried by oxidized plasma proteins, especially albumin and accumulate in subjects with renal disease and coronary artery disease. AOPPs represent an excellent novel marker of oxidative stress and their roles in the development of cardiovascular disease might be of great importance. Here, we show that in vitro-generated AOPP-albumin binds with hig...
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OBJECTIVE Elevated levels of advanced oxidation protein products have been described in several chronic inflammatory diseases, like chronic renal insufficiency, rheumatoid arthritis, and atherosclerosis. Recent findings revealed that advanced oxidation protein products are inhibitors of the major high-density lipoprotein receptor, scavenger receptor class B, type 1 (SR-BI). Here, we investigate...
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2009